How I diagnose and treat neutropenia.

How I Treat

Isolated neutropenia without concomitant anemia or thrombocytopenia is a common clinical problem seen by primary care physicians and hematologists. The etiologies of neutropenia vary from transient suppression by self-limited viral illnesses to previously undetected congenital syndromes to serious systemic diseases. The clinical significance likewise ranges from amild laboratory abnormalitywith...

How I treat How I treat autoimmune lymphoproliferative syndrome

Autoimmune lymphoproliferative syndrome (ALPS) represents a failure of apoptotic mechanisms to maintain lymphocyte homeostasis, permitting accumulation of lymphoid mass and persistence of autoreactive cells that often manifest in childhood with chronic nonmalignant lymphadenopathy, hepatosplenomegaly, and recurring multilineage cytopenias. Cytopenias in these patients can be the result of splen...

How I treat How I treat LGL leukemia

Large granular lymphocyte (LGL) leukemia is characterized by a clonal expansion of either CD3 cytotoxic T or CD3 NK cells. Prominent clinical features of T-LGL leukemia include neutropenia, anemia and rheumatoid arthritis (RA). The terminal effector memory phenotype (CD3 /CD45RA /CD62L CD57 ) of T-LGL suggests a pivotal chronic antigen-driven immune response. LGL survival is then promoted by pl...

Is it time to change how I diagnose, treat, and manage young children with urinary tract infections?

Understanding and treating cytopenia through mathematical modeling.

Here, we briefly review how the study of dynamic hematological diseases with mathematical modeling tools has led to a better understanding of the origin of some types of neutropenia and thrombocytopenia and to improved treatment strategies. In addition, we have briefly discussed how these models suggest improved ways to minimize and/or treat cytopenia induced by chemotherapy.